منابع مشابه
NIH needs a makeover.
This elegantly carved jade face from Liangzhu in southeastern China provides an intriguing glimpse into the beliefs of the people who lived there from 3400 B.C.E. to 2250 B.C.E. As described in a special News Focus section beginning on page 930, discoveries at Liangzhu and other regions far from the traditional heartland of Chinese civilization are revealing surprisingly complex ancient culture...
متن کاملMitotic cells get a stress test
Before they enter mitosis, cells duplicate their centrosomes so that they can form a proper, bipolar mitotic spindle. Cells with only one centrosome—or even no centrosomes at all—can still divide, but they tend to make errors in chromosome segregation. Healthy, nontransformed cells therefore apply the brakes when they lose their centrosomes, and arrest by up-regulating the tumor suppressor p53....
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In this issue of EBioMedicine, Liping Zhao and colleagues show that children with obesity have similar gut microbiota dysbiosis regardless of their geneticmakeup,whether it is simple obesity (no underlying pathology) or genetic obesity (Prader–Willi syndrome). Furthermore, their microbiome profile can be changed by a 1-month dietary intervention. Interestingly, the authors also show that transf...
متن کاملStress fibers from two sources
S tress fi bers arise via two distinct pathways, according to Hotulainen and Lappalainen (page 383). Cells contain at least three different types of contractile actin-based stress fi bers. Transverse arcs do not associate with focal adhesions on either end, whereas ventral stress fi bers contact focal adhesions on both ends. Dorsal stress fi bers have one end tied to a focal adhesion on the ven...
متن کاملPolarity patterns of stress fibers.
Stress fibers are contractile actomyosin bundles commonly observed in the cytoskeleton of metazoan cells. The spatial profile of the polarity of actin filaments inside contractile actomyosin bundles is either monotonic (graded) or periodic (alternating). In the framework of linear irreversible thermodynamics, we write the constitutive equations for a polar, active, elastic one-dimensional mediu...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.09.039